换一批
换一批Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents.
作者：
关键词
1O2, singlet oxygenAD, Alzheimer?s diseaseARE, antioxidant response elementBTB, broad complex, tramtrack and bric-a-bracBach1, BTB and CNC homology 1CBP, cAMP response element binding (CREB) proteinCDDO-Me, bardoxolone methylCOPD, chronic obstructive pulmonary diseaseCTR, C-terminal regionCVD, cardiovascular diseaseDGR, double glycine repeatsDirect inhibitors of protein–protein interactionFITC, flurescein isothiocyanateFP, fluorescence polarizationGCL, glutamate-cysteine ligaseGPx, glutathione peroxidaseGST, glutathione S-transferaseH2O2, hydrogen peroxideHO-1, heme-oxygenase-1HTS, high-throughput screeningHigh throughput screening assaysIBS, inflammatory bowel diseaseIVR, intervening regionKeap1Keap1, Kelch-like ECH-associated protein 1MD, molecular dynamicsNMR, .NO, nitric oxideNQO1, NAD(P)H quinone oxidoreductase INTR, N-terminal regionNrf2Nrf2, nuclear factor erythroid 2–related factor 2Oxidative stressPD, Parkinson?s diseasePPI, protein–protein interactionRNS, reactive nitrogen speciesROS, reactive oxygen speciesSOD, superoxide dismutaseSPR, surface plasmon resonanceSTZ, streptozotocinStructure–activity relationshipsTHIQ, tetrahydroisoquinolineTRX, thioredoxinX-ray crystallography[Formula: see text], peroxynitrate[Formula: see text], superoxide, OH·, hydroxyl radicalvitamin C, ascorbatevitamin E, tocopherols
DOI
10.1016/j.apsb.2015.05.008
PMID
26579458
发布时间
2020-09-30
- 浏览452
Acta pharmaceutica Sinica. B
2015年5卷4期
285-99页
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