The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

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第一作者： Yukiko,Masaki

第一单位： Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi &Co., Ltd., Sapporo 001-0021, Japan.

作者： Yukiko,Masaki ^[1] ; Yoichi,Shimizu ^[2] ; Takeshi,Yoshioka ^[1] ; Yukari,Tanaka ^[3] ; Ken-Ichi,Nishijima ^[4] ; Songji,Zhao ^[5] ; Kenichi,Higashino ^[1] ; Shingo,Sakamoto ^[3] ; Yoshito,Numata ^[1] ; Yoshitaka,Yamaguchi ^[3] ; Nagara,Tamaki ^[5] ; Yuji,Kuge ^[4]

作者单位： Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi &Co., Ltd., Sapporo 001-0021, Japan. ^[1] Central Institute of Isotope Science, Hokkaido University, Sapporo 060-0815, Japan.;Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. ^[2] Shionogi Pharmaceutical Research Center, Research Laboratory for Development, Shionogi &Co., Ltd., Osaka 561-0825, Japan. ^[3] Central Institute of Isotope Science, Hokkaido University, Sapporo 060-0815, Japan.;Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. ^[4] Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan. ^[5]

主题词动物(Animals);诊断显像(Diagnostic Imaging);男(雄)性(Male);质谱分析法(Mass Spectrometry);代谢组(Metabolome);代谢组学(Metabolomics);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);米索硝唑(Misonidazole);分子探针(Molecular Probes);分子量(Molecular Weight);肿瘤(Neoplasms);放射性核素显像(Radionuclide Imaging);结果可重复性(Reproducibility of Results);串联质谱法(Tandem Mass Spectrometry);组织分布(Tissue Distribution)

DOI 10.1038/srep16802

PMID 26582591

发布时间 2018-11-13

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The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

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The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites.

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