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Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts.

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第一作者： Nicole,Wyttenbach

第一单位： Roche Pharmaceutical Research & Early Development, Pre-Clinical CMC, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland.

作者： Nicole,Wyttenbach ^[1] ; Wiebke,Kirchmeyer ^[2] ; Jochem,Alsenz ^[1] ; Martin,Kuentz ^[3]

作者单位： Roche Pharmaceutical Research & Early Development, Pre-Clinical CMC, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[1] Institute of Pharmaceutical Technology, University of Applied Sciences and Arts Northwestern Switzerland , Gründenstrasse 40, 4132 Muttenz, Switzerland.;Institute of Pharmaceutical Technology, University of Basel , Klingelbergstrasse 50, 4056 Basel, Switzerland. ^[2] Institute of Pharmaceutical Technology, University of Applied Sciences and Arts Northwestern Switzerland , Gründenstrasse 40, 4132 Muttenz, Switzerland. ^[3]

关键词 amorphous drug crystallization tendency glass-forming ability in silico prediction undercooled melt

医学主题词化学, 药物(Chemistry, Pharmaceutical);计算机模拟(Computer Simulation);结晶(Crystallization);药物稳定性(Drug Stability);玻璃(Glass);氢键合(Hydrogen Bonding);转变温度(Transition Temperature)

DOI 10.1021/acs.molpharmaceut.5b00688

PMID 26587865

发布时间 2016-01-04

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