Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.
作者:
主题词
姜黄属(Curcuma);姜黄素(Curcumin);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);分子内氧化环原酶类(Intramolecular Oxidoreductases);分子结构(Molecular Structure);异戊烯化(Prenylation);根茎(Rhizome);构效关系(Structure-Activity Relationship)
DOI
10.1021/acs.jnatprod.5b00700
PMID
26588603
发布时间
2016-11-26
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Journal of natural products
2867-79页
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