Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.-论文-万方医学网

第一作者： Andreas,du Bois

第一单位： Kliniken Essen Mitte, Essen, Germany. Electronic address: prof.dubois@googlemail.com.

作者： Andreas,du Bois ^[1] ; Gunnar,Kristensen ^[2] ; Isabelle,Ray-Coquard ^[3] ; Alexander,Reuss ^[4] ; Sandro,Pignata ^[5] ; Nicoletta,Colombo ^[6] ; Ursula,Denison ^[7] ; Ignace,Vergote ^[8] ; Jose M,Del Campo ^[9] ; Petronella,Ottevanger ^[10] ; Martin,Heubner ^[11] ; Thomas,Minarik ^[12] ; Emmanuel,Sevin ^[13] ; Nikolaus,de Gregorio ^[14] ; Mariusz,Bidziński ^[15] ; Jacobus,Pfisterer ^[16] ; Susanne,Malander ^[17] ; Felix,Hilpert ^[18] ; Mansoor R,Mirza ^[19] ; Giovanni,Scambia ^[20] ; Werner,Meier ^[21] ; Maria O,Nicoletto ^[22] ; Line,Bjørge ^[23] ; Alain,Lortholary ^[24] ; Martin Oliver,Sailer ^[25] ; Michael,Merger ^[25] ; Philipp,Harter ^[26] ; AGO Study Group led Gynecologic Cancer Intergroup/European Network of Gynaecologic Oncology Trials Groups Intergroup Consortium

作者单位： Kliniken Essen Mitte, Essen, Germany. Electronic address: prof.dubois@googlemail.com. ^[1] Department of Gynecologic Oncology and Institute for Cancer Genetics and Informatics, Oslo University Hospital, and Oslo University, Oslo, Norway. ^[2] Centre Leon Berard and University of Lyon, Lyon, France. ^[3] Coordinating Center for Clinical Trials, Marburg, Germany. ^[4] National Cancer Institute of Naples, Naples, Italy. ^[5] University of Milan Bicocca, Milan, Italy; European Institute of Oncology Milan, Milan, Italy. ^[6] Health + Life Gesundheitsmanagement GmbH, Vienna, Austria. ^[7] University Hospitals Leuven, Leuven, Belgium. ^[8] Vall d'Hebron University Hospital Barcelona, Barcelona, Spain. ^[9] UMC St Radboud Nijmegen, Nijmegen, Netherlands. ^[10] West German Tumor Center, Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany. ^[11] National Institute of Oncology, Bratislava, Slovakia. ^[12] Centre François Baclesse, Comité Uro-Gynécologie, Caen, France. ^[13] Department of Gynecology, University Hospital, Ulm, Germany. ^[14] Faculty of Health Science, University of Jan Kochanowski, Kielce, Poland. ^[15] Gynecologic Oncology Center, Kiel, Germany. ^[16] University Hospital, Department of Oncology, Lund, Sweden. ^[17] Universitäts-Klinik Schleswig-Holstein (UKSH) Campus Kiel, Department of Gynecology and Obstetrics, Kiel, Germany. ^[18] Rigshospitalet-Copenhagen University Hospital, Department of Oncology, Copenhagen, Denmark. ^[19] Universita Cattolica del Sacro Cuore Policlinico Gemelli, Rome, Italy. ^[20] Evangelisches Krankenhaus, Department of Gynecology and Obstetrics, Duesseldorf, Germany. ^[21] Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico (IRCSS), Oncologia MedicaI, Padova, Italy. ^[22] Haukeland Universitetssykehus, Bergen, Norway. ^[23] Centre Catherine de Sienne, Nantes, France. ^[24] Boehringer Ingelheim, Ingelheim, Germany. ^[25] Kliniken Essen Mitte, Essen, Germany. ^[26]

医学主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);贫血(Anemia);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);卡铂(Carboplatin);癌(Carcinoma);腹泻(Diarrhea);疾病恶化(Disease Progression);无病生存(Disease-Free Survival);双盲法(Double-Blind Method);输卵管肿瘤(Fallopian Tube Neoplasms);女(雌)性(Female);人类(Humans);吲哚类(Indoles);意向治疗分析(Intention to Treat Analysis);中年人(Middle Aged);肿瘤分期(Neoplasm Staging);中性粒细胞减少(Neutropenia);卵巢肿瘤(Ovarian Neoplasms);紫杉酚(Paclitaxel);腹膜肿瘤(Peritoneal Neoplasms);血小板减少(Thrombocytopenia);青年人(Young Adult)

DOI 10.1016/S1470-2045(15)00366-6

PMID 26590673

发布时间 2016-01-13

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Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.

The Lancet. Oncology

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The Lancet. Oncology

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Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.

The Lancet. Oncology

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同项目论文

The Lancet. Oncology

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