换一批
换一批HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
作者：
Michael J,Ombrello [1]
;
Elaine F,Remmers [2]
;
Ioanna,Tachmazidou [3]
;
Alexei,Grom [4]
;
Dirk,Foell [5]
;
Johannes-Peter,Haas [6]
;
Alberto,Martini [7]
;
Marco,Gattorno [8]
;
Seza,Özen [9]
;
Sampath,Prahalad [10]
;
Andrew S,Zeft [11]
;
John F,Bohnsack [12]
;
Elizabeth D,Mellins [13]
;
Norman T,Ilowite [14]
;
Ricardo,Russo [15]
;
Claudio,Len [16]
;
Maria Odete E,Hilario [16]
;
Sheila,Oliveira [17]
;
Rae S M,Yeung [18]
;
Alan,Rosenberg [19]
;
Lucy R,Wedderburn [20]
;
Jordi,Anton [21]
;
Tobias,Schwarz [22]
;
Anne,Hinks [23]
;
Yelda,Bilginer [9]
;
Jane,Park [13]
;
Joanna,Cobb [24]
;
Colleen L,Satorius [2]
;
Buhm,Han [25]
;
Elizabeth,Baskin [26]
;
Sara,Signa [27]
;
Richard H,Duerr [28]
;
J P,Achkar [29]
;
M Ilyas,Kamboh [30]
;
Kenneth M,Kaufman [4]
;
Leah C,Kottyan [4]
;
Dalila,Pinto [31]
;
Stephen W,Scherer [32]
;
Marta E,Alarcón-Riquelme [33]
;
Elisa,Docampo [34]
;
Xavier,Estivill [35]
;
Ahmet,Gül [36]
;
British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group [37]
;
Childhood Arthritis Prospective Study (CAPS) Group [38]
;
Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators [39]
;
Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group [4]
;
Biologically Based Outcome Predictors in JIA (BBOP) Group [3]
;
Paul I W,de Bakker [24]
;
Soumya,Raychaudhuri [40]
;
Carl D,Langefeld [41]
;
Susan,Thompson ;
Eleftheria,Zeggini ;
Wendy,Thomson ;
Daniel L,Kastner ;
Patricia,Woo ;
International Childhood Arthritis Genetics (INCHARGE) Consortium
作者单位：
Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; ombrellomj@mail.nih.gov kastnerd@mail.nih.gov.
[1]
Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;
[2]
Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;
[3]
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;
[4]
Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster, Germany;
[5]
German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany;
[6]
Department of Pediatrics, University of Genova, 16145 Genoa, Italy; Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;
[7]
Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;
[8]
Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;
[9]
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;
[10]
Department of Pediatrics, Cleveland Clinic, Cleveland, OH 44195;
[11]
Department of Pediatrics, University of Utah, Salt Lake City, UT 84113;
[12]
Department of Pediatrics, Stanford University, Stanford, CA 94305;
[13]
Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, NY 10461;
[14]
Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires, Argentina;
[15]
Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;
[16]
Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil;
[17]
Department of Pediatrics, University of Toronto, Toronto, Canada M5S 1A8; Department of Immunology, University of Toronto, Toronto, Canada M5S 1A8; Institute of Medical Science, University of Toronto, Toronto, Canada M5S 1A8;
[18]
Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada S7N 0W8;
[19]
Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom; Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;
[20]
Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona, Spain;
[21]
Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg, Germany;
[22]
Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;
[23]
Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom; National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;
[24]
Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142; Division of Immunology, Allergy, and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736, Republic of Korea;
[25]
Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
[26]
Department of Pediatrics, University of Genova, 16145 Genoa, Italy;
[27]
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261;
[28]
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195; Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195;
[29]
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
[30]
Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, NY 10029;
[31]
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada;
[32]
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016, Spain;
[33]
Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège, Belgium; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;
[34]
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;
[35]
Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey;
[36]
Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands; Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands; and.
[37]
Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142; Division of Immunology, Allergy, and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;
[38]
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27106.
[39]
Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; ombrellomj@mail.nih.gov kastnerd@mail.nih.gov.
[40]
Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;
[41]
主题词
儿童(Child);基因频率(Gene Frequency);疾病遗传易感性(Genetic Predisposition to Disease);基因型(Genotype);单倍型(Haplotypes);组织相容性抗原Ⅱ类(Histocompatibility Antigens Class II);人类(Humans);连锁不平衡(Linkage Disequilibrium);Meta分析(主题)(Meta-Analysis as Topic);比值比(Odds Ratio);多态性, 单核苷酸(Polymorphism, Single Nucleotide);危险因素(Risk Factors)
DOI
10.1073/pnas.1520779112
PMID
26598658
发布时间
2022-03-19
- 浏览38
Proceedings of the National Academy of Sciences of the United States of America
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