Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster.

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作者： Lawrence B,Mensah ^[1] ; Claire,Davison ^[1] ; Shih-Jung,Fan ^[1] ; John F,Morris ^[1] ; Deborah C I,Goberdhan ^[1] ; Clive,Wilson ^[1]

作者单位： Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, United Kingdom. ^[1]

主题词动物(Animals);果蝇蛋白质类(Drosophila Proteins);黑腹果蝇(Drosophila melanogaster);女(雌)性(Female);PTEN磷酸水解酶(PTEN Phosphohydrolase);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);蛋白质结合(Protein Binding);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction)

DOI 10.1371/journal.pone.0143818

PMID 26599788

发布时间 2022-01-29

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2015年10卷11期

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Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster.

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Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster.

PloS one

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