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Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.

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第一作者： Scott N,Furlan

第一单位： Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, the University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle WA 98101, USA.

作者： Scott N,Furlan ^[1] ; Benjamin,Watkins ^[2] ; Victor,Tkachev ^[1] ; Ryan,Flynn ^[3] ; Sarah,Cooley ^[3] ; Swetha,Ramakrishnan ^[2] ; Karnail,Singh ^[2] ; Cindy,Giver ^[2] ; Kelly,Hamby ^[2] ; Linda,Stempora ^[2] ; Aneesah,Garrett ^[2] ; Jingyang,Chen ^[1] ; Kayla M,Betz ^[1] ; Carly G K,Ziegler ^[4] ; Gregory K,Tharp ^[5] ; Steven E,Bosinger ^[5] ; Daniel E L,Promislow ^[6] ; Jeffrey S,Miller ^[3] ; Edmund K,Waller ^[2] ; Bruce R,Blazar ^[3] ; Leslie S,Kean ^[7]

作者单位： Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, the University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle WA 98101, USA. ^[1] Emory University School of Medicine, Atlanta, GA 30322, USA. ^[2] Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA. ^[3] Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ^[5] Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA. ^[6] Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, the University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle WA 98101, USA. leslie.kean@seattlechildrens.org. ^[7]

医学主题词基因表达(Gene Expression);移植物抗宿主病(Graft vs Host Disease);人类(Humans);甲氨蝶呤(Methotrexate);西罗莫司(Sirolimus);他罗利姆(Tacrolimus)

DOI 10.1126/scitranslmed.aad3231

PMID 26606970

发布时间 2024-06-10

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准确一般字义偏差语意偏离译文作用小提交