Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells.

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第一作者： Sun-Mi,Yun

第一单位： Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-706, Republic of Korea.

作者： Sun-Mi,Yun ^[1] ; Sang Hyeok,Woo ^[2] ; Sang Taek,Oh ^[3] ; Sung-Eun,Hong ^[1] ; Tae-Boo,Choe ^[4] ; Sang-Kyu,Ye ^[5] ; Eun-Kyu,Kim ^[6] ; Min Ki,Seong ^[7] ; Hyun-A,Kim ^[7] ; Woo Chul,Noh ^[7] ; Jin Kyung,Lee ^[8] ; Hyeon-Ok,Jin ^[8] ; Yun-Han,Lee ^[9] ; In-Chul,Park ^[10]

作者单位： Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-706, Republic of Korea. ^[1] Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-706, Republic of Korea; KIRAMS Radiation Biobank, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-709, Republic of Korea. ^[2] Department of Radiation Oncology, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea. ^[3] Department of Microbiological Engineering, Kon-Kuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea. ^[4] Department of Pharmacology, Seoul National University College of Medicine, 103 Daehangno, Jongno-gu Seoul 110-799, Republic of Korea. ^[5] Department of Surgery, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyenggi-do 463-707, Republic of Korea. ^[6] Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea. ^[7] KIRAMS Radiation Biobank, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-709, Republic of Korea. ^[8] Department of Radiation Oncology, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea. Electronic address: yhlee87@yuhs.ac. ^[9] Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 139-706, Republic of Korea. Electronic address: parkic@kirams.re.kr. ^[10]

关键词 Apoptotic cell death Arsenic trioxide Melatonin Redd1 mTORC1