Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.

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作者： Moshe,Goldsmith ^[1] ; Simone,Eckstein ^[2] ; Yacov,Ashani ^[1] ; Per,Greisen ^[3] ; Haim,Leader ^[4] ; Joel L,Sussman ^[5] ; Nidhi,Aggarwal ^[5] ; Sergey,Ovchinnikov ^[3] ; Dan S,Tawfik ^[1] ; David,Baker ^[3] ; Horst,Thiermann ^[2] ; Franz,Worek ^[6]

作者单位： Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel. ^[1] Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany. ^[2] Institute for Protein Design and Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA. ^[3] Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, Israel. ^[4] Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel. ^[5] Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany. franzworek@bundeswehr.org. ^[6]

关键词 Bioscavenger Detoxification Mutant Organophosphate hydrolase Organophosphorus compounds Phosphotriesterase