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Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.

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第一作者： Mark,Ammirati

第一单位： Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Research Unit, External Research Solutions, Primary Pharmacology Group, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.

作者： Mark,Ammirati ^[1] ; Scott W,Bagley ^[1] ; Samit K,Bhattacharya ^[1] ; Leonard,Buckbinder ^[1] ; Anthony A,Carlo ^[1] ; Rebecca,Conrad ^[1] ; Christian,Cortes ^[1] ; Robert L,Dow ^[1] ; Matthew S,Dowling ^[1] ; Ayman,El-Kattan ^[1] ; Kristen,Ford ^[1] ; Cristiano R W,Guimarães ^[1] ; David,Hepworth ^[1] ; Wenhua,Jiao ^[1] ; Jennifer,LaPerle ^[1] ; Shenping,Liu ^[1] ; Allyn,Londregan ^[1] ; Paula M,Loria ^[1] ; Alan M,Mathiowetz ^[1] ; Michael,Munchhof ^[1] ; Suvi T M,Orr ^[1] ; Donna N,Petersen ^[1] ; David A,Price ^[1] ; Athanasia,Skoura ^[1] ; Aaron C,Smith ^[1] ; Jian,Wang ^[1]

作者单位： Worldwide Medicinal Chemistry, Cardiovascular and Metabolic Research Unit, External Research Solutions, Primary Pharmacology Group, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States. ^[1]

关键词 HGK MAP4K4 MAP4K4 inhibitor P-loop PF-6260933 ZC1 kinase inhibitor

DOI 10.1021/acsmedchemlett.5b00215

PMID 26617966

发布时间 2020-09-29

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