Identification and Preliminary SAR Analysis of Novel Type-I Inhibitors of TIE-2 via Structure-Based Virtual Screening and Biological Evaluation in in vitro Models.
第一作者:
Peichen,Pan
第一单位:
Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , Suzhou, Jiangsu 215123, China.
作者:
主题词
生物学鉴定法(Biological Assay);结晶学, X线(Crystallography, X-Ray);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);酶激活(Enzyme Activation);半数抑制浓度(Inhibitory Concentration 50);蛋白激酶抑制剂(Protein Kinase Inhibitors);受体, TIE-2(Receptor, TIE-2);构效关系(Structure-Activity Relationship)
DOI
10.1021/acs.jcim.5b00576
PMID
26618892
发布时间
2016-12-30
- 浏览11
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文