Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish.

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作者： Leigh Ann,Samsa ^[1] ; Chris,Givens ^[1] ; Eleni,Tzima ^[2] ; Didier Y R,Stainier ^[3] ; Li,Qian ^[4] ; Jiandong,Liu ^[5]

作者单位： Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA McAllister Heart Institute, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[1] Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA McAllister Heart Institute, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. ^[2] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany. ^[3] McAllister Heart Institute, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[4] McAllister Heart Institute, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA jiandong_liu@med.unc.edu. ^[5]

关键词 Blood flow Cardiac chamber maturation Cardiac contraction Neuregulin 1 Notch Primary cilia Trabeculation Zebrafish