Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.-论文-万方医学网

第一作者： Xiaoming,Zha

第一单位： State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , 24 Tongjiaxiang, Nanjing 210009, P. R. China.

作者： Xiaoming,Zha ^[1] ; Doriano,Lamba ^[2] ; Lili,Zhang ^[1] ; Yinghan,Lou ^[1] ; Changxu,Xu ^[1] ; Di,Kang ^[1] ; Li,Chen ^[1] ; Yungen,Xu ^[3] ; Luyong,Zhang ^[2] ; Angela,De Simone ^[4] ; Sarah,Samez ^[2] ; Alessandro,Pesaresi ^[5] ; Jure,Stojan ^[6] ; Manuela G,Lopez ^[6] ; Javier,Egea ^[3] ; Vincenza,Andrisano ^[7] ; Manuela,Bartolini

作者单位： State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , 24 Tongjiaxiang, Nanjing 210009, P. R. China. ^[1] Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park - Basovizza , S.S. no. 14 Km 163.5, I-34149 Trieste, Italy. ^[2] Department for Life Quality Studies, University of Bologna , Corso d'Augusto 237, I-47921 Rimini, Italy. ^[3] Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste , Via L. Giorgieri 1, I-34127 Trieste, Italy. ^[4] Institute of Biochemistry, Medical Faculty, University of Ljubljana , Vrazov trg 2, SI-1000 Ljubljana, Slovenia. ^[5] Instituto Teófilo Hernando, Department of Pharmacology, Universidad Autónoma de Madrid , C/Arzobispo Morcillo 4, 28029 Madrid, Spain. ^[6] Department of Pharmacy and Biotechnology, University of Bologna , Via Belmeloro 6, I-40126 Bologna, Italy. ^[7]

主题词阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);动物(Animals);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);行为, 动物(Behavior, Animal);苯呋喃类(Benzofurans);细胞系(Cell Line);细胞存活(Cell Survival);胆碱酯酶抑制剂(Cholinesterase Inhibitors);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交ICR(Mice, Inbred ICR);模型, 分子(Models, Molecular);脑代谢改善药(Nootropic Agents);构效关系(Structure-Activity Relationship);他克林(Tacrine);电鳐(Torpedo)

DOI 10.1021/acs.jmedchem.5b01119

PMID 26632651

发布时间 2016-11-26

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Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

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