Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.

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第一作者： Francis,Rajamohan

第一单位： Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.

作者： Francis,Rajamohan ^[1] ; Allan R,Reyes ^[2] ; Richard K,Frisbie ^[3] ; Lise R,Hoth ^[1] ; Parag,Sahasrabudhe ^[1] ; Rachelle,Magyar ^[1] ; James A,Landro ^[2] ; Jane M,Withka ^[1] ; Nicole L,Caspers ^[1] ; Matthew F,Calabrese ^[1] ; Jessica,Ward ^[2] ; Ravi G,Kurumbail ^[4]

作者单位： Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ^[1] CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A. ^[2] The Department of Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ^[3] Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ravi.g.kurumbail@pfizer.com. ^[4]

关键词 AMP-activated protein kinase (AMPK)allosteric activation heterotrimeric complex kinase activity metabolic sensor recombinant protein