Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.

导出 LinkOut

翻译打印收藏纠错

第一作者： David,Bier

第一单位： Department of Chemistry, University of Duisburg-Essen, Universitätstr. 7, 45141, Essen, Germany.

作者： David,Bier ^[1] ; Maria,Bartel ^[2] ; Katharina,Sies ^[3] ; Sebastian,Halbach ^[3] ; Yusuke,Higuchi ^[4] ; Yu,Haranosono ^[5] ; Tilman,Brummer ^[6] ; Nobuo,Kato ^[6] ; Christian,Ottmann ^[7]

作者单位： Department of Chemistry, University of Duisburg-Essen, Universitätstr. 7, 45141, Essen, Germany. ^[1] Department of Biomedical Engineering, Institute for Complex Molecular, Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands. ^[2] Institute of Molecular Medicine & Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 17, 79104, Freiburg, Germany. ^[3] Faculty of Biology, University of Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany. ^[4] Spemann Graduate School of Biology & Medicine, University of Freiburg, Albertstr. 19A, 79104 Freiburg, Germany. ^[5] The Institute of Scientific & Industrial Research, Osaka University, Osaka, 567-0047, Japan. ^[6] Institute of Molecular Medicine & Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 17, 79104, Freiburg, Germany. tilman.brummer@mail.zbsa.uni-freiburg.de. ^[7] BIOSS: Centre for Biological Signaling Studies, University of Freiburg, Schänzlestr. 18, 79104 Freiburg, Germany. tilman.brummer@mail.zbsa.uni-freiburg.de. ^[8] The Institute of Scientific & Industrial Research, Osaka University, Osaka, 567-0047, Japan. kato-n@sanken.osaka-u.ac.jp. ^[9] Department of Chemistry, University of Duisburg-Essen, Universitätstr. 7, 45141, Essen, Germany. christian.ottmann@uni-due.de, c.ottmann@tue.nl. ^[10] Department of Biomedical Engineering, Institute for Complex Molecular, Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands. christian.ottmann@uni-due.de, c.ottmann@tue.nl. ^[11]

关键词 X-ray protein crystallography natural products protein-protein interactions semi-synthesis small molecules