Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).

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作者： Dominik H,Pesta ^[1] ; Rachel J,Perry ^[2] ; Fitsum,Guebre-Egziabher ^[3] ; Dongyan,Zhang ^[4] ; Michael,Jurczak ^[5] ; Antje,Fischer-Rosinsky ^[1] ; Martin A,Daniels ^[2] ; Diana M,Willmes ^[6] ; Sanjay,Bhanot ^[1] ; Stefan R,Bornstein ^[2] ; Felix,Knauf ^[1] ; Varman T,Samuel ^[7] ; Gerald I,Shulman ^[7] ; Andreas L,Birkenfeld ^[8]

作者单位： Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. ^[1] Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. ^[2] Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria. ^[3] Department of Visceral, Transplant, and Thoracic Surgery, D. Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria. ^[4] Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Düsseldorf, German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany. ^[5] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. ^[6] Charité - University School of Medicine, Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany. ^[7] Section of Metabolic Vascular Medicine, Medical Clinic III and Paul Langerhans Institute Dresden (PLID), TU Dresden, Germany. ^[8] German Center for Diabetes Research (DZD), Dresden, Germany. ^[9] Isis Pharmaceuticals, Carlsbad, CA, USA. ^[10] Section of Diabetes and Nutritional Sciences, Rayne Institute, King's College London, London, UK. ^[11] University Clinic Erlangen, Erlangen, Germany. ^[12] Veterans Affairs Medical Center, West Haven, CT, USA. ^[13]

关键词 Indy Slc13a5 aging hepatic insulin resistance type 2 diabetes