MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.

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作者： Elena,Chiavacci ^[1] ; Romina,D'Aurizio ^[2] ; Elena,Guzzolino ^[3] ; Francesco,Russo ^[2] ; Mario,Baumgart ^[4] ; Marco,Groth ^[5] ; Laura,Mariani ^[5] ; Mara,D'Onofrio ^[1] ; Ivan,Arisi ^[6] ; Marco,Pellegrini ^[6] ; Alessandro,Cellerino ^[2] ; Federico,Cremisi ^[7] ; Letizia,Pitto ^[7]

作者单位： Institute of Clinical Physiology, National Research Council, via Moruzzi 1, 56124 Pisa, Italy. ^[1] Laboratory of Integrative Systems Medicine (LISM), Institute of Informatics andTelematics (IIT) and Institute of Clinical Physiology (IFC), (CNR), Pisa, Italy. ^[2] Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy. ^[3] Department of Computer Science, University of Pisa, Pisa, Italy. ^[4] Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstr. 11, 07745 Jena, Germany. ^[5] Genomics Facility, European Brain Research Institute, Via del Fosso di Fiorano 64 00143 Roma, Italy. ^[6] Scuola Normale Superiore di Pisa, Piazza dei Cavalieri 7, 56100 Pisa, Italy. ^[7]

主题词畸形, 多发性(Abnormalities, Multiple);动物鳍(Animal Fins);动物(Animals);胚胎发育(Embryonic Development);基因表达调控, 发育期(Gene Expression Regulation, Developmental);全基因组关联研究(Genome-Wide Association Study);基因组学(Genomics);心脏缺损, 先天性(Heart Defects, Congenital);房间隔缺损(Heart Septal Defects, Atrial);下肢畸形, 先天性(Lower Extremity Deformities, Congenital);微RNAs(MicroRNAs);多基因族(Multigene Family);表型(Phenotype);RNA干扰(RNA Interference);T盒域蛋白质类(T-Box Domain Proteins);上肢畸形, 先天性(Upper Extremity Deformities, Congenital);斑马鱼(Zebrafish)

DOI 10.1038/srep18240

PMID 26657204

发布时间 2018-11-13

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MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.

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MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.

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