The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.-论文-万方医学网

作者： Huan-Tian,Zhang ^[1] ; Ling-Fei,Zeng ^[2] ; Qing-Yu,He ^[3] ; W Andy,Tao ^[2] ; Zhen-Gang,Zha ^[4] ; Chang-Deng,Hu ^[5]

作者单位： Institute of Orthopedic Diseases and Department of Orthopedics, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China; Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. ^[1] Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA. ^[2] Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ^[3] Institute of Orthopedic Diseases and Department of Orthopedics, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China. Electronic address: zhzgg@vip.163.com. ^[4] Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: hu1@purdue.edu. ^[5]

主题词动物(Animals);细胞凋亡(Apoptosis);苯醌类(Benzoquinones);COS细胞(COS Cells);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);HEK293细胞(HEK293 Cells);人类(Humans);免疫印迹法(Immunoblotting);内酰胺类, 大环(Lactams, Macrocyclic);赖氨酸(Lysine);模型, 生物学(Models, Biological);突变(Mutation);聚泛素(Polyubiquitin);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白质结合(Protein Binding);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);RNA干扰(RNA Interference);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination)

DOI 10.1016/j.bbamcr.2015.12.001

PMID 26658161

发布时间 2019-12-10

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The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.

Biochimica et biophysica acta

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The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.

Biochimica et biophysica acta

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Biochimica et biophysica acta

相关期刊

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