Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.-论文-万方医学网

作者： Laura,Schnöder ^[1] ; Wenlin,Hao ^[1] ; Yiren,Qin ^[1] ; Shirong,Liu ^[2] ; Inge,Tomic ^[1] ; Xu,Liu ^[1] ; Klaus,Fassbender ^[1] ; Yang,Liu ^[3]

作者单位： From the Department of Neurology, Saarland University, 66421 Homburg/Saar, Germany, the German Institute for Dementia Prevention (DIDP), Saarland University, 66421 Homburg/Saar, Germany, and. ^[1] the Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115. ^[2] From the Department of Neurology, Saarland University, 66421 Homburg/Saar, Germany, the German Institute for Dementia Prevention (DIDP), Saarland University, 66421 Homburg/Saar, Germany, and a.liu@mx.uni-saarland.de. ^[3]

主题词阿尔茨海默病(Alzheimer Disease);淀粉样蛋白(Amyloid);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);动物(Animals);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);生物转运(Biological Transport);脑(Brain);细胞系, 肿瘤(Cell Line, Tumor);疾病模型, 动物(Disease Models, Animal);遗传载体(Genetic Vectors);人类(Humans);炎症(Inflammation);溶酶体(Lysosomes);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);突变(Mutation);神经元(Neurons);磷酰化(Phosphorylation);信号传导(Signal Transduction);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1074/jbc.M115.695916

PMID 26663083

发布时间 2022-03-17

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Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.

The Journal of biological chemistry

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The Journal of biological chemistry

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Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.

The Journal of biological chemistry

相似文献

The Journal of biological chemistry

相关期刊

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