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Placebo-controlled study in neuromyelitis optica-Ethical and design considerations.

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第一作者： Bruce Ac,Cree

第一单位： Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA bruce.cree@ucsf.edu.

作者： Bruce Ac,Cree ^[1] ; Jeffrey L,Bennett ^[2] ; Mark,Sheehan ^[3] ; Jeffrey,Cohen ^[4] ; Hans-Peter,Hartung ^[5] ; Orhan,Aktas ^[5] ; Ho Jin,Kim ^[6] ; Friedemann,Paul ^[7] ; Sean,Pittock ^[8] ; Brian,Weinshenker ^[8] ; Dean,Wingerchuk ^[9] ; Kazuo,Fujihara ^[10] ; Gary,Cutter ^[11] ; Kaushik,Patra ^[12] ; Armando,Flor ^[12] ; Gerard,Barron ^[13] ; Soraya,Madani ^[12] ; John N,Ratchford ^[12] ; Eliezer,Katz ^[12]

作者单位： Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA bruce.cree@ucsf.edu. ^[1] Program in Neuroscience, Departments of Neurology and Ophthalmology, University of Colorado, Denver, CO, USA. ^[2] The Ethox Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK. ^[3] Cleveland Clinic, Cleveland, OH, USA. ^[4] Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Berlin, Germany. ^[5] Research Institute and Hospital of National Cancer Center, Goyang, South Korea. ^[6] Charite-University Medicine Berlin, Berlin, Germany. ^[7] Mayo Clinic, Rochester, MN, USA. ^[8] Mayo Clinic, Scottsdale, AZ, USA. ^[9] Tohoku University, Sendai, Japan. ^[10] The University of Alabama at Birmingham, Birmingham, AL, USA. ^[11] MedImmune, Gaithersburg, MD, USA. ^[12] MedImmune, Cambridge, UK. ^[13]

关键词 MEDI-551 Neuromyelitis optica anti-CD19 monoclonal antibody ethics trial design

医学主题词伦理学, 研究(Ethics, Research);人类(Humans);免疫因子类(Immunologic Factors);视神经脊髓炎(Neuromyelitis Optica);研究设计(Research Design);时间因素(Time Factors);治疗结果(Treatment Outcome)

DOI 10.1177/1352458515620934

PMID 26666258

发布时间 2019-12-10

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准确一般字义偏差语意偏离译文作用小提交