A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.

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第一作者： Alexander,Drilon

第一单位： Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Weill Cornell Medical College, New York, New York. drilona@mskcc.org davarem@ohsu.edu.

作者： Alexander,Drilon ^[1] ; Romel,Somwar ^[2] ; Jacob P,Wagner ^[3] ; Nadeem A,Vellore ^[4] ; Christopher A,Eide ^[5] ; Matthew S,Zabriskie ^[4] ; Maria E,Arcila ^[6] ; Jaclyn F,Hechtman ^[6] ; Lu,Wang ^[6] ; Roger S,Smith ^[2] ; Mark G,Kris ^[7] ; Gregory J,Riely ^[7] ; Brian J,Druker ^[5] ; Thomas,O'Hare ^[4] ; Marc,Ladanyi ^[8] ; Monika A,Davare ^[9]

作者单位： Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Weill Cornell Medical College, New York, New York. drilona@mskcc.org davarem@ohsu.edu. ^[1] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. ^[2] Knight Cancer Institute and Department of Pediatrics, Oregon Health & Science University, Portland, Oregon. ^[3] Huntsman Cancer Institute and Division of Hematology and Hematologic Malignancies, The University of Utah, Salt Lake City, Utah. ^[4] Knight Cancer Institute and Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon. Howard Hughes Medical Institute, Portland, Oregon. ^[5] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[6] Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Weill Cornell Medical College, New York, New York. ^[7] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[8] Knight Cancer Institute and Department of Pediatrics, Oregon Health & Science University, Portland, Oregon. drilona@mskcc.org davarem@ohsu.edu. ^[9]