Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.

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作者： Gwanghyun,Jung ^[1] ; Giovanni,Fajardo ^[1] ; Alexandre J S,Ribeiro ^[1] ; Kristina Bezold,Kooiker ^[1] ; Michael,Coronado ^[1] ; Mingming,Zhao ^[1] ; Dong-Qing,Hu ^[1] ; Sushma,Reddy ^[1] ; Kazuki,Kodo ^[1] ; Krishna,Sriram ^[1] ; Paul A,Insel ^[1] ; Joseph C,Wu ^[1] ; Beth L,Pruitt ^[1] ; Daniel,Bernstein ^[2]

作者单位： *Division of Cardiology, Department of Pediatrics, Stanford Cardiovascular Institute, Division of Cardiovascular Medicine, Department of Medicine, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA; Department of Mechanical Engineering, Stanford University School of Engineering, Stanford, California, USA; and Departments of Pharmacology and Medicine, University of California, San Diego, San Diego, California, USA. ^[1] *Division of Cardiology, Department of Pediatrics, Stanford Cardiovascular Institute, Division of Cardiovascular Medicine, Department of Medicine, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA; Department of Mechanical Engineering, Stanford University School of Engineering, Stanford, California, USA; and Departments of Pharmacology and Medicine, University of California, San Diego, San Diego, California, USA danb@stanford.edu. ^[2]

关键词 cardiotoxicity testing cell signaling maturation β-adrenergic receptor