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A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules.

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第一作者： Hong,Shan

第一单位： Department of Biophysics, College of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.

作者： Hong,Shan ^[1] ; Zihao,Wang ^[2] ; Fa,Zhang ^[3] ; Yong,Xiong ^[4] ; Chang-Cheng,Yin ^[5] ; Fei,Sun ^[6]

作者单位： Department of Biophysics, College of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. ^[1] Key Lab of Intelligent Information Processing and Advanced Computing Research Lab, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, China.;University of Chinese Academy of Sciences, Beijing, 100049, China. ^[2] Key Lab of Intelligent Information Processing and Advanced Computing Research Lab, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, China. ^[3] Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA. ^[4] Department of Biophysics, College of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. ccyin@hsc.pku.edu.cn. ^[5] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. feisun@ibp.ac.cn.;University of Chinese Academy of Sciences, Beijing, 100049, China. feisun@ibp.ac.cn.;Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. feisun@ibp.ac.cn. ^[6]

关键词 conformational heterogeneity cryo-electron microscopy local optimization refinement rigid module single particle analysis