Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.-论文-万方医学网

作者： Ruth B,Siboni ^[1] ; Masayuki,Nakamori ^[2] ; Stacey D,Wagner ^[1] ; Adam J,Struck ^[1] ; Leslie A,Coonrod ^[1] ; Shanee A,Harriott ^[3] ; Daniel M,Cass ^[3] ; Matthew K,Tanner ^[1] ; J Andrew,Berglund ^[4]

作者单位： Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA. ^[1] Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. ^[2] Department of Chemistry, Reed College, Portland, OR 97202, USA. ^[3] Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: aberglund@ufl.edu. ^[4]

主题词动物(Animals);碱基序列(Base Sequence);量热法(Calorimetry);氯化物通道(Chloride Channels);DNA结合蛋白质类(DNA-Binding Proteins);更生霉素(Dactinomycin);疾病模型, 动物(Disease Models, Animal);鸟嘌呤核苷酸交换因子类(Guanine Nucleotide Exchange Factors);人类(Humans);小鼠(Mice);显微镜检查, 荧光(Microscopy, Fluorescence);营养不良性肌强直(Myotonic Dystrophy);RNA(RNA);RNA剪接(RNA Splicing);RNA, 信使(RNA, Messenger);RNA结合蛋白质类(RNA-Binding Proteins);肌浆网钙转运ATP酶类(Sarcoplasmic Reticulum Calcium-Transporting ATPases);序列分析, RNA(Sequence Analysis, RNA);转录, 遗传(Transcription, Genetic);三核苷酸重复扩增(Trinucleotide Repeat Expansion);膜泡运输蛋白质类(Vesicular Transport Proteins)

DOI 10.1016/j.celrep.2015.11.028

PMID 26686629

发布时间 2020-12-09

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Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.

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Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.

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