Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

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第一作者： Yasir A,Syed

第一单位： Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK.;Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075, Goettingen, Germany.

作者： Yasir A,Syed ^[1] ; Chao,Zhao ^[2] ; Don,Mahad ^[3] ; Wiebke,Möbius ^[4] ; Friedrich,Altmann ^[5] ; Franziska,Foss ^[6] ; G A,González ^[6] ; Aycan,Sentürk ^[6] ; Amparo,Acker-Palmer ^[7] ; Gert,Lubec ^[8] ; Kathryn,Lilley ^[2] ; Robin J M,Franklin ^[4] ; Klaus-A,Nave ^[9] ; Mark R N,Kotter

作者单位： Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK.;Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075, Goettingen, Germany. ^[1] Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK. ^[2] Centre for Neuroregeneration, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. ^[3] Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075, Goettingen, Germany. ^[4] Department of Chemistry, University of Natural Resource and Life Sciences, Muthgasse 18, 1190, Vienna, Austria. ^[5] Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany. ^[6] Department of Pediatrics, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.;Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 4, 1090, Vienna, Austria. ^[7] Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK. ^[8] Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK. mrk25@cam.ac.uk.;Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075, Goettingen, Germany. mrk25@cam.ac.uk.;Universitätsmedizin Göttingen, Universitätsklinik für Neurochirurgie, Robert-Koch-Straße 40, 37075, Göttingen, Germany. mrk25@cam.ac.uk. ^[9]

关键词 EphrinB3 Multiple sclerosis Oligodendrocytes Remyelination