Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential in HLA-Matched and -Mismatched Donor-Recipient Pairs.

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作者： Badar,Abdul Razzaq ^[1] ; Allison,Scalora ^[2] ; Vishal N,Koparde ^[3] ; Jeremy,Meier ^[2] ; Musa,Mahmood ^[1] ; Salman,Salman ^[1] ; Max,Jameson-Lee ^[2] ; Myrna G,Serrano ^[3] ; Nihar,Sheth ^[3] ; Mark,Voelkner ^[4] ; David J,Kobulnicky ^[2] ; Catherine H,Roberts ^[2] ; Andrea,Ferreira-Gonzalez ^[4] ; Masoud H,Manjili ^[5] ; Gregory A,Buck ^[3] ; Michael C,Neale ^[6] ; Amir A,Toor ^[7]

作者单位： Virginia Commonwealth University School of Engineering, Virginia Commonwealth University, Richmond, VA 23298. ^[1] Bone Marrow Transplant Program, Massey Cancer Center & Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298. ^[2] Center for Biological Complexity, Virginia Commonwealth University, Richmond, VA 23298. ^[3] Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298. ^[4] Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298. ^[5] Department of Psychiatry and Statistical Genomics, Virginia Commonwealth University, Richmond, VA 23298. ^[6] Bone Marrow Transplant Program, Massey Cancer Center & Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298. Electronic address: amir.toor@vcuhealth.org. ^[7]

关键词 Dynamic system GVHD HLA Histocompatibility Logistic equation Operators Stem cell transplantation Vectors Whole exome sequencing