Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications.

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作者： Ken-ichiro,Matsunaga ^[1] ; Michiko,Kimoto ^[2] ; Charlotte,Hanson ^[3] ; Michael,Sanford ^[1] ; Howard A,Young ^[2] ; Ichiro,Hirao ^[3]

作者单位： Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669. ^[1] TagCyx Biotechnologies, 1-6-126 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ^[2] RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ^[3] PRESTO, JST, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan. ^[4] Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD, 21702 USA. ^[5]

主题词适体, 核苷(Aptamers, Nucleotide);碱基序列(Base Sequence);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);干扰素γ(Interferon-gamma);核酸构象(Nucleic Acid Conformation);受体, 干扰素(Receptors, Interferon);SELEX适体技术(SELEX Aptamer Technique)

DOI 10.1038/srep18478

PMID 26690672

发布时间 2018-11-13

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Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications.

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Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications.

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