Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.

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第一作者： Dong,An

第一单位： Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, 110004, China.

作者： Dong,An ^[1] ; Xiaowei,Wei ^[2] ; Hui,Li ^[1] ; Hui,Gu ^[1] ; Tianchu,Huang ^[1] ; Guifeng,Zhao ^[1] ; Bo,Liu ^[1] ; Weilin,Wang ^[1] ; Lizhu,Chen ^[3] ; Wei,Ma ^[1] ; Henan,Zhang ^[1] ; Songying,Cao ^[1] ; Zhengwei,Yuan ^[1]

作者单位： Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, 110004, China. ^[1] Department of Pediatrics,The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. ^[2] Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang, 110004, China. ^[3]

主题词羊水(Amniotic Fluid);动物(Animals);胚胎, 哺乳动物(Embryo, Mammalian);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);女(雌)性(Female);胎儿(Fetus);同位素标记(Isotope Labeling);分子序列注释(Molecular Sequence Annotation);神经管缺损(Neural Tube Defects);胎盘(Placenta);妊娠(Pregnancy);产前诊断(Prenatal Diagnosis);前蛋白转化酶类(Proprotein Convertases);蛋白质组学(Proteomics);大鼠(Rats);结果可重复性(Reproducibility of Results);丝氨酸内肽酶类(Serine Endopeptidases);囊肿性脊柱裂(Spina Bifida Cystica)

DOI 10.1038/srep17559

PMID 26691006

发布时间 2018-11-13

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Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.

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Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics.

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