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SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of <i>Toxoplasma gondii</i> CDPK1.

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第一作者： Wenlin,Huang

第一单位： Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States.

作者： Wenlin,Huang ^[1] ; Kayode K,Ojo ^[2] ; Zhongsheng,Zhang ^[1] ; Kasey,Rivas ^[2] ; Rama Subba Rao,Vidadala ^[3] ; Suzanne,Scheele ^[4] ; Amy E,DeRocher ^[4] ; Ryan,Choi ^[2] ; Matthew A,Hulverson ^[2] ; Lynn K,Barrett ^[2] ; Igor,Bruzual ^[5] ; Latha Kallur,Siddaramaiah ^[1] ; Keshia M,Kerchner ^[1] ; Matthew D,Kurnick ^[6] ; Gail M,Freiberg ^[6] ; Dale,Kempf ^[6] ; Wim G J,Hol ^[1] ; Ethan A,Merritt ^[1] ; Georg,Neckermann ^[7] ; Eugenio L,de Hostos ^[7] ; Nina,Isoherranen ^[8] ; Dustin J,Maly ^[3] ; Marilyn,Parsons ^[9] ; J Stone,Doggett ^[5] ; Wesley C,Van Voorhis ^[10] ; Erkang,Fan ^[1]

作者单位： Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States. ^[1] Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States. ^[2] Department of Chemistry, University of Washington , Seattle, Washington 98195, United States. ^[3] Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States. ^[4] Portland VA Medical Center , Portland, Oregon 97239, United States. ^[5] AbbVie , N. Chicago, Illinois 60064, United States. ^[6] PATH , San Francisco, California 94102, United States. ^[7] Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States. ^[8] Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States ; Department of Global Health, University of Washington , Seattle, Washington 98195, United States. ^[9] Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States ; Department of Global Health, University of Washington , Seattle, Washington 98195, United States. ^[10]

关键词 Toxoplasma gondii calcium-dependent protein kinase-1 enzyme inhibitor structure?activity relationship studies

DOI 10.1021/acsmedchemlett.5b00319

PMID 26693272

发布时间 2020-10-01

基金项目

IK2 BX002440/BX/BLRD VA/United States P51 OD011132/OD/NIH HHS/United States R01 AI089441/AI/NIAID NIH HHS/United States

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