Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.

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作者： Wentao,Chen ^[1] ; Jiajia,Dong ^[2] ; Suhua,Li ^[1] ; Yu,Liu ^[1] ; Yujia,Wang ^[1] ; Leonard,Yoon ^[3] ; Peng,Wu ^[1] ; K Barry,Sharpless ^[1] ; Jeffery W,Kelly ^[1]

作者单位： Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. ^[1] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. ^[2] The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. ^[3] Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. sharples@scripps.edu. ^[4] The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. sharples@scripps.edu. ^[5] Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. jkelly@scripps.edu. ^[6] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. jkelly@scripps.edu. ^[7] The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA. jkelly@scripps.edu. ^[8]

关键词 SuFEx click chemistry peptides solid-phase synthesis sulfotyrosine

主题词氨基酸序列(Amino Acid Sequence);氨基酸类(Amino Acids);芴类(Fluorenes);分子序列数据(Molecular Sequence Data);肽类(Peptides);酪氨酸(Tyrosine)

DOI 10.1002/anie.201509016

PMID 26696445

发布时间 2018-11-13

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