Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.-论文-万方医学网

作者： Giorgio,Mauri ^[1] ; Elena,Jachetti ^[1] ; Barbara,Comuzzi ^[1] ; Matteo,Dugo ^[2] ; Ivano,Arioli ^[1] ; Silvia,Miotti ^[1] ; Sabina,Sangaletti ^[1] ; Emma,Di Carlo ^[3] ; Claudio,Tripodo ^[4] ; Mario P,Colombo ^[5]

作者单位： Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, 20133, Milano, Italy. ^[1] Functional Genomics and Bioinformatics, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, 20133, Milano, Italy. ^[2] Department of Medicine and Science of Aging, Section of Anatomic Pathology and Molecular Medicine, "G. d'Annunzio" University, 66100, Chieti, Italy. ^[3] Ce.S.I. Aging Research Center, "G. d'Annunzio" University Foundation, 66100, Chieti, Italy. ^[4] Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90127, Palermo, Italy. ^[5]

主题词腺癌(Adenocarcinoma);动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞转化, 肿瘤(Cell Transformation, Neoplastic);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);荧光抗体技术(Fluorescent Antibody Technique);基因缺失(Gene Deletion);基因表达谱(Gene Expression Profiling);人类(Humans);免疫酶技术(Immunoenzyme Techniques);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);神经内分泌瘤(Neuroendocrine Tumors);骨桥蛋白质(Osteopontin);前列腺肿瘤(Prostatic Neoplasms);RNA, 信使(RNA, Messenger);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)

DOI 10.18632/oncotarget.6678

PMID 26700622

发布时间 2018-11-13

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Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

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Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

Oncotarget

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Oncotarget

相关期刊

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