换一批Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure.
第一作者：
Robert,Elsby
第一单位：
DMPK, Drug Safety and Metabolism (R.E., D.S.), and Quantitative Clinical Pharmacology, (P.M.), AstraZeneca R&D Alderley Park, Macclesfield, Cheshire, United Kingdom; and DMPK, Drug Safety and Metabolism, AstraZeneca R&D Darwin, Cambridge, Cambridgeshire, United Kingdom (P.S., K.F.).
作者：
医学主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);氨基吡啶类(Aminopyridines);曲线下面积(Area Under Curve);生物转运(Biological Transport);Caco-2细胞(Caco-2 Cells);药物相互作用(Drug Interactions);HEK293细胞(HEK293 Cells);人类(Humans);羟甲基戊二酰基CoA还原酶抑制剂(Hydroxymethylglutaryl-CoA Reductase Inhibitors);肠吸收(Intestinal Absorption);肝(Liver);膜转运蛋白质类(Membrane Transport Proteins);吗啉类(Morpholines);肿瘤蛋白质类(Neoplasm Proteins);有机阴离子转运子(Organic Anion Transporters);恶嗪类(Oxazines);吡啶类(Pyridines);嘧啶类(Pyrimidines)
DOI
10.1124/dmd.115.066795
PMID
26700956
发布时间
2025-02-12
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