Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons.

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作者： Paraskevi,Krashia ^[1] ; Ada,Ledonne ^[1] ; Annalisa,Nobili ^[2] ; Alberto,Cordella ^[3] ; Francesco,Errico ^[4] ; Alessandro,Usiello ^[5] ; Marcello,D'Amelio ^[2] ; Nicola Biagio,Mercuri ^[3] ; Ezia,Guatteo ^[6] ; Irene,Carunchio ^[3]

作者单位： Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. ^[1] Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Medicine, Unit of Molecular Neurosciences, University Campus-Biomedico, Rome, Italy. ^[2] Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy. ^[3] Ceinge Biotecnologie Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy. ^[4] Ceinge Biotecnologie Avanzate, Naples, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples (SUN), Caserta, Italy. ^[5] Department of Experimental Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. Electronic address: e.guatteo@hsantalucia.it. ^[6]

关键词 D-aspartate oxidase knockout Excitatory amino-acid transporter L-Aspartate Midbrain dopamine neuron NMDA receptor Substantia nigra pars compacta