Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

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作者： Kenji,Imai ^[1] ; Tomomi,Kotani ^[2] ; Hiroyuki,Tsuda ^[1] ; Yukio,Mano ^[1] ; Tomoko,Nakano ^[1] ; Takafumi,Ushida ^[1] ; Hua,Li ^[1] ; Rika,Miki ^[3] ; Seiji,Sumigama ^[1] ; Akira,Iwase ^[1] ; Akihiro,Hirakawa ^[4] ; Kinji,Ohno ^[5] ; Shinya,Toyokuni ^[6] ; Hideyuki,Takeuchi ^[7] ; Tetsuya,Mizuno ^[7] ; Akio,Suzumura ^[7] ; Fumitaka,Kikkawa ^[1]

作者单位： Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[1] Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: itoto@med.nagoya-u.ac.jp. ^[2] Laboratory of Bell Research Centre-Department of Obstetrics and Gynecology Collaborative Research, Bell Research Centre for Reproductive Health and Cancer, Department of Reproduction, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[3] Biostatistics Section, Center for Advanced Medicine and Clinical Research Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[4] Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[5] Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[6] Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. ^[7]

关键词 FIRS IL-6 Inflammation ROS

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);脑(Brain);脑损伤(Brain Injuries);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);女(雌)性(Female);氢(Hydrogen);脂多糖类(Lipopolysaccharides);小鼠, 近交ICR(Mice, Inbred ICR);小神经胶质细胞(Microglia);神经保护药(Neuroprotective Agents);氧化性应激(Oxidative Stress);妊娠(Pregnancy);妊娠并发症(Pregnancy Complications);活性氧(Reactive Oxygen Species)

DOI 10.1016/j.freeradbiomed.2015.12.015

PMID 26709014

发布时间 2016-12-30

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Free radical biology & medicine

2016年91卷

154-63页

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Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

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Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

Free radical biology & medicine

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