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Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

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第一作者： Vsevolod,Telezhkin

第一单位： School of Biosciences, Cardiff University, Cardiff, United Kingdom;

作者： Vsevolod,Telezhkin ^[1] ; Christian,Schnell ^[1] ; Polina,Yarova ^[1] ; Sun,Yung ^[1] ; Emma,Cope ^[1] ; Alis,Hughes ^[1] ; Belinda A,Thompson ^[1] ; Philip,Sanders ^[2] ; Charlene,Geater ^[1] ; Jane M,Hancock ^[3] ; Shona,Joy ^[1] ; Luned,Badder ^[1] ; Natalie,Connor-Robson ^[1] ; Andrea,Comella ^[2] ; Marco,Straccia ^[2] ; Georgina,Bombau ^[2] ; Jon T,Brown ^[4] ; Josep M,Canals ^[2] ; Andrew D,Randall ^[5] ; Nicholas D,Allen ^[6] ; Paul J,Kemp ^[1]

作者单位： School of Biosciences, Cardiff University, Cardiff, United Kingdom; ^[1] Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain; ^[2] School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; and. ^[3] Hatherly Laboratory, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom. ^[4] School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; and Hatherly Laboratory, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom. ^[5] School of Biosciences, Cardiff University, Cardiff, United Kingdom; Allennd@cf.ac.uk. ^[6]

关键词 EPSCs GABAA embryonic stem cells iPSCs induced pluripotent stem cells neural differentiation neuronal maturation patch clamp