Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.

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第一作者： Nora,Kuhlmann

第一单位： From the Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, University of Cologne, 50931 Cologne, Germany.

作者： Nora,Kuhlmann ^[1] ; Sarah,Wroblowski ^[1] ; Philipp,Knyphausen ^[1] ; Susanne,de Boor ^[1] ; Julian,Brenig ^[1] ; Anke Y,Zienert ^[2] ; Katrin,Meyer-Teschendorf ^[2] ; Gerrit J K,Praefcke ^[3] ; Hendrik,Nolte ^[1] ; Marcus,Krüger ^[1] ; Magdalena,Schacherl ^[4] ; Ulrich,Baumann ^[4] ; Leo C,James ^[5] ; Jason W,Chin ^[5] ; Michael,Lammers ^[6]

作者单位： From the Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, University of Cologne, 50931 Cologne, Germany. ^[1] the Institute for Genetics, Zülpicher Strasse 47a, University of Cologne, 50674 Cologne, Germany. ^[2] the Institute for Genetics, Zülpicher Strasse 47a, University of Cologne, 50674 Cologne, Germany,; the Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany, and. ^[3] the Institute for Biochemistry, Zülpicher Strasse 47, University of Cologne, 50674 Cologne, Germany. ^[4] the Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom. ^[5] From the Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, University of Cologne, 50931 Cologne, Germany,. Electronic address: michael.lammers@uni-koeln.de. ^[6]

关键词 Ras homolog gene family, member A (RhoA)Rho (Rho GTPase)acetylation acetyltransferase guanine-nucleotide-dissociation inhibitor alpha histone deacetylase (HDAC)lysine acetylation lysine acetyltransferase post-translational modification (PTM)sirtuin