首页> JAMA> Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.

Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.

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第一作者： Najib M,Rahman

第一单位： Oxford Respiratory Trials Unit and Oxford Pleural Diseases Unit, Churchill Hospital, Oxford, England2National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, England.

作者： Najib M,Rahman ^[1] ; Justin,Pepperell ^[2] ; Sunita,Rehal ^[3] ; Tarek,Saba ^[4] ; Augustine,Tang ^[4] ; Nabeel,Ali ^[5] ; Alex,West ^[6] ; Gihan,Hettiarachchi ^[6] ; Dipak,Mukherjee ^[7] ; Johnson,Samuel ^[7] ; Andrew,Bentley ^[8] ; Lee,Dowson ^[9] ; Jonathan,Miles ^[10] ; C Frank,Ryan ^[11] ; Ken Y,Yoneda ^[12] ; Anoop,Chauhan ^[13] ; John P,Corcoran ^[14] ; Ioannis,Psallidas ^[14] ; John M,Wrightson ^[1] ; Rob,Hallifax ^[14] ; Helen E,Davies ^[15] ; Y C Gary,Lee ^[16] ; Melissa,Dobson ^[14] ; Emma L,Hedley ^[14] ; Douglas,Seaton ^[17] ; Nicky,Russell ^[14] ; Margaret,Chapman ^[14] ; Bethan M,McFadyen ^[14] ; Rachel A,Shaw ^[14] ; Robert J O,Davies ^[14] ; Nick A,Maskell ^[18] ; Andrew J,Nunn ^[3] ; Robert F,Miller ^[19]

作者单位： Oxford Respiratory Trials Unit and Oxford Pleural Diseases Unit, Churchill Hospital, Oxford, England2National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, England. ^[1] Somerset Lung Centre, Musgrove Park Hospital, Taunton, England. ^[2] Medical Research Council Clinical Trials Unit at University College London, London, England. ^[3] Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, England. ^[4] King's Mill Hospital, Mansfield, England. ^[5] Medway Maritime Hospital, Gillingham, England. ^[6] Basildon University Hospital, Basildon, England. ^[7] University Hospital of South Manchester NHS Foundation Trust, Manchester, England. ^[8] Royal Wolverhampton Hospital NHS Trust, Wolverhampton, England. ^[9] Rotherham General Hospital, Rotherham, England. ^[10] Vancouver Coastal Health, Vancouver, British Columbia, Canada. ^[11] University of California, Davis, Medical Center, Sacramento. ^[12] Queen Alexandra Hospital, Portsmouth, England. ^[13] Oxford Respiratory Trials Unit and Oxford Pleural Diseases Unit, Churchill Hospital, Oxford, England. ^[14] Cardiff and Vale University Health Board, Cardiff, Wales. ^[15] School of Medicine and Centre for Asthma, Allergy, and Respiratory Research, University of Western Australia, Crawley, Australia. ^[16] Department of Respiratory Medicine, Ipswich Hospital, Ipswich, England. ^[17] Academic Respiratory Unit, Department of Clinical Sciences, Southmead Hospital, University of Bristol, Bristol, England. ^[18] Research Department of Infection and Population Health, Institute of Epidemiology and Healthcare, University College London, London, England. ^[19]