6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.

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第一作者： Abdalla E A,Hassan

第一单位： Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; Applied Nucleic Acids Research Centre, Zagazig University, Zagazig, PO Box 44519, Egypt. Electronic address: abdallaelsayed@zu.edu.eg.

作者： Abdalla E A,Hassan ^[1] ; Reham A I,Abou-Elkhair ^[2] ; William B,Parker ^[3] ; Paula W,Allan ^[4] ; John A,Secrist ^[4]

作者单位： Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; Applied Nucleic Acids Research Centre, Zagazig University, Zagazig, PO Box 44519, Egypt. Electronic address: abdallaelsayed@zu.edu.eg. ^[1] Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; Applied Nucleic Acids Research Centre, Zagazig University, Zagazig, PO Box 44519, Egypt. ^[2] Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; PNP Therapeutics Inc., 15 Richard Arrington Jr. Blvd North, Birmingham, AL, 35203, USA. ^[3] Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA. ^[4]

关键词 2-Fluoroadenine 6-Methylpurine Cancer gene therapy Prodrugs Purine nucleoside phosphorylase