Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.

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作者： Chengyu,Zou ^[1] ; Yuan,Shi ^[2] ; Jasmin,Ohli ^[3] ; Ulrich,Schüller ^[4] ; Mario M,Dorostkar ^[1] ; Jochen,Herms ^[2]

作者单位： Department for Translational Brain Research, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[1] Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany. ^[2] Munich Cluster of Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Schillerstraße 44, 80336, Munich, Germany. ^[3] Graduate School of Systemic Neuroscience, Ludwig-Maximilians-University, Munich, Germany. ^[4] Department for Translational Brain Research, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. jochen.herms@med.uni-muenchen.de. ^[5] Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany. jochen.herms@med.uni-muenchen.de. ^[6] Munich Cluster of Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Schillerstraße 44, 80336, Munich, Germany. jochen.herms@med.uni-muenchen.de. ^[7]

关键词 APPswe/PS1deltaE9 mice Dendritic spines Neuroinflammation Preclinical AD Structural plasticity