Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.

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作者： Soichiro,Yoshikawa ^[1] ; Takako,Usami ^[2] ; Junichi,Kikuta ^[3] ; Masaru,Ishii ^[3] ; Tetsuo,Sasano ^[4] ; Koji,Sugiyama ^[5] ; Tetsushi,Furukawa ^[5] ; Eiji,Nakasho ^[6] ; Hiroshi,Takayanagi ^[7] ; Thomas F,Tedder ^[8] ; Hajime,Karasuyama ^[1] ; Atsushi,Miyawaki ^[9] ; Takahiro,Adachi ^[10]

作者单位： Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan. ^[1] Laboratory of recombinant animals, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan. ^[2] Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan. ^[3] Department of Biofunctional Informatics, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. ^[4] Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. ^[5] R&D Group, Scientific Solutions Product Development Division, Olympus Corporation, Hachioji-shi, Tokyo 192-8507, Japan. ^[6] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. ^[7] Department of Immunology, Duke University Medical Center, Durham, NC 27710. ^[8] Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan. ^[9] Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan. ^[10]

主题词动物(Animals);抗原, CD19(Antigens, CD19);自身免疫疾病(Autoimmune Diseases);自身免疫(Autoimmunity);生物传感技术(Biosensing Techniques);骨髓(Bone Marrow);钙(Calcium);钙信号(Calcium Signaling);疾病模型, 动物(Disease Models, Animal);基因表达(Gene Expression);基因, 报告(Genes, Reporter);淋巴细胞(Lymphocytes);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);分子显像(Molecular Imaging);淋巴集结(Peyer's Patches);重组融合蛋白质类(Recombinant Fusion Proteins);脾(Spleen)

DOI 10.1038/srep18738

PMID 26732477

发布时间 2018-11-13

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Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.

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Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.

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