Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

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作者： Michelle,Vincendeau ^[1] ; Kamyar,Hadian ^[1] ; Ana C,Messias ^[2] ; Jara K,Brenke ^[3] ; Jenny,Halander ^[4] ; Richard,Griesbach ^[2] ; Ute,Greczmiel ^[3] ; Arianna,Bertossi ^[1] ; Ralf,Stehle ^[1] ; Daniel,Nagel ^[1] ; Katrin,Demski ^[3] ; Hana,Velvarska ^[4] ; Dierk,Niessing ^[1] ; Arie,Geerlof ^[1] ; Michael,Sattler ^[3] ; Daniel,Krappmann ^[3]

作者单位： Research Unit Cellular Signal Integration, Helmholtz Zentrum München für Gesundheit und Umwelt, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. ^[1] Assay Development and Screening Platform, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München für Gesundheit und Umwelt, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. ^[2] Institute of Structural Biology, Helmholtz Zentrum München für Gesundheit und Umwelt, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. ^[3] Center for Integrated Protein Science Munich at Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany. ^[4] Biomedical Center of the Ludwig-Maximilians University München, Department of Cell Biology, Großhadener Str. 9, 82152 Planegg-Martinsried, Germany. ^[5] Protein Expression and Purification Facility, Institute of Structural Biology, Helmholtz Zentrum München für Gesundheit und Umwelt, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. ^[6]

主题词动物(Animals);蒽醌类(Anthraquinones);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);白细胞介素1β(Interleukin-1beta);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);小鼠(Mice);NF-κB(NF-kappa B);蛋白质结合(Protein Binding);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);信号传导(Signal Transduction);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);泛素(Ubiquitin);泛素化(Ubiquitination)

DOI 10.1038/srep18934

PMID 26740240

发布时间 2018-11-13

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Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

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Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

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