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首页> Bioorganic & medicinal chemistry> New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.

New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.

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作者： Krzysztof,Kamiński ^[1] ; Mirosław,Zagaja ^[2] ; Anna,Rapacz ^[3] ; Jarogniew J,Łuszczki ^[4] ; Marta,Andres-Mach ^[2] ; Michał,Abram ^[5] ; Jolanta,Obniska ^[5]

作者单位： Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. Electronic address: k.kaminski@uj.edu.pl. ^[1] Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland. ^[2] Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. ^[3] Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland; Department of Pathophysiology, Medical University of Lublin, Ceramiczna 1, 20-150 Lublin, Poland. ^[4] Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland. ^[5]

关键词 Anticonvulsant activity Hybrid compounds In vivo studies MES test Pyrrolidine-2,5-dione Six-Hertz (6Hz) test Succinimide scPTZ test

主题词镇痛药(Analgesics);动物(Animals);抗惊厥药(Anticonvulsants);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);电休克(Electroshock);注射, 腹腔内(Injections, Intraperitoneal);小鼠(Mice);分子结构(Molecular Structure);疼痛(Pain);疼痛测定(Pain Measurement);戊四唑(Pentylenetetrazole);哌嗪类(Piperazines);吡咯烷酮类(Pyrrolidinones);发作(Seizures)

DOI 10.1016/j.bmc.2015.12.027

PMID 26746343

发布时间 2016-12-30

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Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

2016年24卷4期

606-18页

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