Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease.

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第一作者： Pingping,Song

第一单位： State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, 300071, China.

作者： Pingping,Song ^[1] ; Shanshan,Li ^[1] ; Hao,Wu ^[2] ; Ruize,Gao ^[1] ; Guanhua,Rao ^[1] ; Dongmei,Wang ^[3] ; Ziheng,Chen ^[2] ; Biao,Ma ^[1] ; Hongxia,Wang ^[1] ; Nan,Sui ^[3] ; Haiteng,Deng ^[4] ; Zhuohua,Zhang ^[5] ; Tieshan,Tang ^[2] ; Zheng,Tan ^[2] ; Zehan,Han ^[6] ; Tieyuan,Lu ^[7] ; Yushan,Zhu ^[8] ; Quan,Chen ^[9]

作者单位： State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, 300071, China. ^[1] State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ^[2] Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. ^[3] College of Life Sciences, Tsinghua University, Beijing, 100084, China. ^[4] State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Changsha, 410078, China. ^[5] Department of Health and Sports Science, Tianjin University of Sport, Tianjin, 300381, China. ^[6] Department of Health and Sports Science, Tianjin University of Sport, Tianjin, 300381, China. tjlutieyuan@aliyun.com. ^[7] State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, 300071, China. zhuys@nankai.edu.cn. ^[8] State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, 300071, China. chenq@ioz.ac.cn.;State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. chenq@ioz.ac.cn. ^[9]

关键词 parkin sequestosome1/p62 substantia nigra ubiquitin