Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
第一作者:
Longfei,Jia
第一单位:
Key Laboratory of Animal Physiology &Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P. R. China.
作者:
主题词
动物(Animals);碳(Carbon);DNA甲基化(DNA Methylation);DNA, 线粒体(DNA, Mitochondrial);女(雌)性(Female);鱼类(Fishes);基因剂量(Gene Dosage);基因表达调控(Gene Expression Regulation);基因, 线粒体(Genes, Mitochondrial);膜电位, 线粒体(Membrane Potential, Mitochondrial);代谢网络和途径(Metabolic Networks and Pathways);线粒体(Mitochondria);卵母细胞(Oocytes);多囊卵巢综合征(Polycystic Ovary Syndrome);蛋白质转运(Protein Transport);阻遏蛋白质类(Repressor Proteins)
DOI
10.1038/srep19436
PMID
26758245
发布时间
2018-11-13
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