Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.

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作者： Shelley L,Baumgardt ^[1] ; Mark,Paterson ^[1] ; Thorsten M,Leucker ^[1] ; Juan,Fang ^[1] ; David X,Zhang ^[1] ; Zeljko J,Bosnjak ^[1] ; David C,Warltier ^[1] ; Judy R,Kersten ^[1] ; Zhi-Dong,Ge ^[2]

作者单位： From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD (T.M.L.). ^[1] From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD (T.M.L.). Wilson.ge99@gmail.com. ^[2]

关键词 diabetic cardiomyopathy ischemia reperfusion injury nitric oxide synthase tetrahydrobiopterin type 2 diabetes mellitus