Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

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作者： Jianping,Hu ^[1] ; Xin,Wang ^[1] ; Lin,Chen ^[1] ; Min,Huang ^[2] ; Wei,Tang ^[2] ; Jianping,Zuo ^[2] ; Yu-Chih,Liu ^[3] ; Zhe,Shi ^[3] ; Rongfeng,Liu ^[3] ; Jingkang,Shen ^[4] ; Bing,Xiong ^[5]

作者单位： Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ^[1] Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ^[2] Shanghai ChemPartner Co. LTD, Building 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China. ^[3] Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: jkshen@simm.ac.cn. ^[4] Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: bxiong@simm.ac.cn. ^[5]

关键词 Chelating group Epigenetics GSK-J1 Histone demethylase JMJD3 inhibitors