Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.
第一作者:
Fuxia,Xiong
第一单位:
Institute for Fetology and Reproductive Medicine Center, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
作者:
主题词
动物(Animals);动物, 新生(Animals, Newborn);阿扎胞苷(Azacitidine);结合部位(Binding Sites);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);外显子(Exons);女(雌)性(Female);男(雄)性(Male);母亲暴露(Maternal Exposure);心肌再灌注损伤(Myocardial Reperfusion Injury);氧(Oxygen);表型(Phenotype);妊娠(Pregnancy);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 糖皮质激素(Receptors, Glucocorticoid);反应元件(Response Elements);Sp1转录因子(Sp1 Transcription Factor)
DOI
10.1016/j.yjmcc.2016.01.003
PMID
26779948
发布时间
2022-03-10
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