Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.

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作者： Tom,Ronan ^[1] ; Jennifer L,Macdonald-Obermann ^[2] ; Lorel,Huelsmann ^[2] ; Nicholas J,Bessman ^[3] ; Kristen M,Naegle ^[4] ; Linda J,Pike ^[5]

作者单位： From the Department of Biomedical Engineering and Center for Biological Systems Engineering and. ^[1] Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 and. ^[2] the Department of Biochemistry and Biophysics, Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104-6059. ^[3] From the Department of Biomedical Engineering and Center for Biological Systems Engineering and. Electronic address: knaegle@wustl.edu. ^[4] Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 and. Electronic address: pike@biochem.wustl.edu. ^[5]

关键词 cancer biology epidermal growth factor (EGF)epidermal growth factor receptor (EGFR)growth factor receptor tyrosine kinase systems biology

主题词动物(Animals);CHO细胞(CHO Cells);仓鼠属(Cricetulus);表皮生长因子(Epidermal Growth Factor);配体(Ligands);信号传导(Signal Transduction)

DOI 10.1074/jbc.M115.710087

PMID 26786109

发布时间 2022-03-10

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