Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

导出原文传递

翻译打印收藏纠错

作者： Mark E,Layton ^[1] ; Alexander J,Reif ^[1] ; Timothy J,Hartingh ^[1] ; Kevin,Rodzinak ^[1] ; Vadim,Dudkin ^[1] ; Cheng,Wang ^[1] ; Ken,Arrington ^[1] ; Michael J,Kelly ^[1] ; Robert M,Garbaccio ^[1] ; Julie A,O'Brien ^[2] ; Brian C,Magliaro ^[3] ; Jason M,Uslaner ^[4] ; Sarah L,Huszar ^[4] ; Kerry L,Fillgrove ^[5] ; Cuyue,Tang ^[5] ; Yuhsin,Kuo ^[5] ; Marlene A,Jacobson ^[3]

作者单位： Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States. ^[1] Department of In Vitro Sciences, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States. ^[2] Department of Psychiatry Research, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States. ^[3] Department of Central Pharmacology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States. ^[4] Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States. ^[5]

关键词 Metabotropic glutamate receptor Positive allosteric modulator Schizophrenia mGlu2 PAM